Wayne County Vacation Packages 2026 from $616

Photo by Isaac Richardson

Plan, book, travel with confidence
Better together
Save up to $2,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Your Wayne County Vacation

Set off on your next thrilling adventure with a Wayne County vacation package, and leave relaxed knowing the finer details are taken care of. Plus with the ability to tailor your escape, it'll be one to remember. A trip to Wayne County wouldn't be complete without spending a few nights in Piedmont. This city is among the best places to visit here. Whether you plan to travel on a shoestring or want to splurge, Expedia are here to help you tailor-make your next Wayne County vacation.

Top destinations in Wayne County

A gravel path leading to a stone structure with a triangular roof, surrounded by trees and a road.

The Latest Wayne County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Holiday Inn Express & Suites Perryville by IHG

$616

per person

Dec 26 - Dec 30

found 1 day ago

Roundtrip flight included

Baltimore (BWI) to Cape Girardeau (CGI)

9.2/10 Wonderful! (630 reviews)

LOVE the double bench available for 2 suitcases! Top notch, KUDOS on that little thing that meant so much to us as seniors. Breakfast was good, rooms were clean, restaurant was nice. An overall exceptional experience. This stay moved Holiday Inn Express up a few notches on my list.

Reviewed on Oct 21, 2026

Find the Best Wayne County Vacation Packages

Wayne County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Top Sights	Lake Wappapello, Clearwater Lake and Lake Wappapello State Park

Wayne County Hotel Deals

Sam A Baker State Park

5732 State Hwy Missouri 143 Patterson MO

$150 nightly

$159 total

Oct 25 - Oct 26

Total with taxes and fees

9/10 Wonderful! (6 reviews)

"Janie and her staff were great and very flexible. We had all the hep we needed for everything. Will comeback asap!"

Reviewed on Dec 29, 2025

Secluded in the woods, couple’s romantic cabin & hot tub, brkfast foods provided

Greenville MO

Fully refundable

$292 nightly

$307 total

Nov 2 - Nov 3

Total with taxes and fees

10/10 Exceptional! (13 reviews)

"The Fox Den is a groovy get away for anyone wanting to relax and unwind, the night time dips in hot tub were a perfect way to end the days. We enjoyed a wonderful selection of LPs as background to our weekend."

Reviewed on Oct 19, 2026

Fall Getaway Cabin Bordering Mark Twain National Forest w/Fire Pit & Trails

Mill Spring MO

$165 nightly

$174 total

Oct 25 - Oct 26

Total with taxes and fees

9.8/10 Exceptional! (6 reviews)

"Love how it was decorated"

Reviewed on Oct 4, 2026

See all 216 properties in Wayne County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Wayne County attractions

A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

See properties