Wayne County Vacations & Trips from $857

Book a Hotel + Flight or Car together to unlock savings

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Your Wayne County Vacation

Set off on your next thrilling adventure with a Wayne County vacation package, and leave relaxed knowing the finer details are taken care of. Plus with the ability to tailor your escape, it'll be one to remember. A trip to Wayne County wouldn't be complete without spending a few nights in Piedmont. This city is among the best places to visit here. Whether you plan to travel on a shoestring or want to splurge, Expedia are here to help you tailor-make your next Wayne County vacation.

Top destinations in Wayne County

The Latest Wayne County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Riverview
Rockwood Inn
Courtyard by Marriott Cape Girardeau Downtown
Fairfield Inn & Suites by Marriott Cape Girardeau
Makanda Inn

Find the Best Wayne County Vacation Packages

Wayne County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Top Sights
Lake Wappapello, Clearwater Lake and Lake Wappapello State Park

Wayne County Hotel Deals

Private lake, beach & hot tub,  romantic getaway or family vaca

Private lake, beach & hot tub, romantic getaway or family vaca

Wappapello MO
9.8/10 Exceptional! (43 reviews)
"Husband and I were looking for a quiet secluded getaway where we could fish. So we rented this property for 2 nights. The house was very very clean. Didn't take advantage of the hot tub but it looked to be a large size. Lake is actually a shared pond with neighbors but we had fun fishing it. Was ..."

Reviewed on May 20, 2026

Private lake, beach & hot tub, romantic getaway or family vaca
Camp Minnow Beach House

Camp Minnow Beach House

Wappapello MO
9.4/10 Exceptional! (16 reviews)
"Overall a great stay. Just wish there was a guest accessible WiFi."

Reviewed on May 16, 2026

Camp Minnow Beach House
Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!

Greenville MO
$115 nightly
The price is $121 total per night from Jun 9 to Jun 10
$121 total
Jun 9 - Jun 10
Total with taxes and fees
10/10 Exceptional! (4 reviews)
"This was easily the best property I've ever stayed at. Holly was SO friendly and kind, and made sure that we had everything we needed for the weekend! The cabin is clean and well-appointed, and the spot is quiet and peaceful, with beautiful clear night skies. I genuinely plan to come back next ..."

Reviewed on Apr 27, 2026

Cozy hobby farm cabin under the stars!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.